Sheikh Radwan of Gaza City was located nearly 3 kilometers (1.9 mi) northwest of the city center. It bordered al-Shati camp to the southwest, Rimal to the south, and Jabalia to the east. The Sheikh Radwan Cemetery was located in the district. It contained hundreds of graves for Palestinians killed in the Israeli–Palestinian conflict, including Hamas leaders Ahmed Yassin, Abdel Aziz al-Rantissi, and Said Siam.

During the Gaza war, the neighborhood was subjected to heavy bombing by Israel, resulting in "unprecedented destruction", including the destruction of homes, mosques, and public areas.

In August 2024, it was reported that the Sheikh Radwan Lagoon had become polluted by sewage and stagnant rainwater as the result of the area's sanitation systems being damaged by the Gaza war. The lack of infrastructure had led to increase in water-born disease, including polio, hepatitis A, and cholera, and skin infections. The United Nations established vaccination clinic in Sheikh Radwan in November 2024 to distribute the polio vaccine to Palestinian children. The clinic was bombed a few hours after opening, injuring two adults and four children. The Israeli war belligerent and Hamas both denied responsibility for the attack.