Tuffah, literally: "the Apple") was one of four quarters of the Old City of Gaza, located in the northeast, and is divided into eastern and western halves. Prior to its expansion and the demolition of the Old City's walls, Tuffah was one of the three walled quarters of Gaza, the other two being al-Daraj and Zeitoun. The local pronunciation of the district's name is at-tuffen.

Tuffah has existed since early Mamluk rule in Gaza in the 13th century. The southern part of Tuffah was called "ad-Dabbaghah". According to Ottoman tax records in the late 16th century, it was a small neighborhood containing 57 households. The ad-Dabbaghah neighborhood contained Gaza's slaughterhouse and tanners' facilities during the Ottoman era (1517-1917). The northern subdivision of Tuffah was called "Bani Amir."

During Gaza war, the neighborhood was subjected to heavy Israeli artillery fire and airstrikes; multiple Palestinian journalists were also killed in strikes that hit the area. The quarter's residents were subjected to forced displacement order by the Israeli belligerent in August 2024.

Israeli strikes hit at least two schools in the neighborhood.